CAPA-IVF

What is CAPA-IVF?

  • CAPA-IVF* is a disruptive new fertility technology.
  • CAPA-IVF enables a more natural way of obtaining mature oocytes for IVF and social freezing without the burden and risks of systemic ovarian stimulation.
  • CAPA-IVF aims to provide an alternative safe and effective option for infertile couples, and when seeking oocytes and embryo preservation for future fertility.

* US and European patents granted in 2019, Chinese patent pending
* * Voung et al., Human Reproduction 2020

Principle of CAPA-IVF – Treating the oocyte

Key Publications in CAPA-IVF

Basic Research

  • Romero S, et al.: Immature oocytes from unprimed juvenile mice become a valuable source for embryo production when using c-type natriuretic peptide as essential component of culture medium.
    Biol Reprod. 2016;95:64.
  • Sanchez F, et al.: An improved IVM method for cumulus-oocyte complexes from small follicles in polycystic ovary syndrome patients enhances  oocyte competence and embryo yield.
    Hum Reprod. 2017;32:2056-68.

Safety Data

  • Saenz De Juano MD, et al.: DNA methylation and mRNA expression of imprinted genes in blastocysts derived from an improved IVM method for  oocytes from small follicles in PCOS patients.
    Hum Reprod. 2019: Aug 9. pii: dez121.

Clinical Trials

Proof-of-concept: standard IVM versus CAPA-IVF (n= 40)

  • Sanchez F,  et al.: Biphasic in vitro maturation (CAPA-IVM) specifically improves the developmental capacity of oocytes from small antral follicles.
    Journal of Assist Reprod Genet. 2019 Aug 9. doi: 10.1007/s10815-019-01551-5.

Randomized clinical trial: standard IVM versus CAPA-IVF (n = 80)

  • Vuong L. , et al.: Live Births after oocyte in vitro maturation with prematuration step in women with polycystic ovary syndrome.
    Journal of Assist Reprod  Genet. 2020, 37(2):347-357.

Randomized clinical trial: standard IVF versus CAPA-IVF in ICSI (n = 546)

  • Vuong L, et al.:  In-vitro maturation of oocytes versus conventional IVF in women with infertility and a high antral follicle count: a randomized non-inferiority controlled trial.
    Hum Reprod.  2020 Nov 1;35(11):2537-2547.
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